Marijuana or Ganja or Cannabis has been the subject of much research in recent years, and studies have shown that its active compounds could be beneficial for treating rheumatoid arthritis (RA).
RA is a chronic autoimmune disease that causes inflammation and pain in the joints, leading to disability. Here are some points supported by research paper evidence of the benefits of active compounds of marijuana in rheumatoid arthritis:
- Cannabinoids, the active compounds in marijuana, have anti-inflammatory properties, which is crucial as inflammation plays a significant role in the development and progression of RA. A study published in the Journal of Pharmacology and Experimental Therapeutics found that cannabinoids can reduce inflammation in a model of RA in rats. Source
- Cannabinoids also have analgesic properties, which means they can help to relieve pain. This is essential for people with RA who often experience chronic pain in their joints. A study published in the journal Current Opinion in Rheumatology found that cannabinoids can reduce pain in patients with RA. Source
- A study published in the journal Rheumatology found that patients with RA who used a cannabis-based medicine experienced a significant reduction in pain and an improvement in sleep quality compared to those who received a placebo. Source
- Cannabinoids have immunomodulatory effects, which means they can help to regulate the immune system. This is essential in the treatment of autoimmune diseases like RA, where the immune system attacks healthy tissue in the body. A study published in the journal Annals of Rheumatic Diseases found that cannabinoids can modulate the immune system in a way that reduces inflammation in RA. Source
- Cannabidiol (CBD), another cannabinoid found in marijuana, has been shown to have anti-inflammatory and immunomodulatory effects without the psychoactive effects of THC. A study published in the journal PLoS One found that CBD can reduce inflammation in a model of RA in rats. Source
- A review published in the journal Future Medicinal Chemistry found that CBD has the potential to be a safe and effective treatment for RA, with fewer side effects than traditional medications. The authors noted that further research is needed to determine the optimal doses and formulations of CBD for RA. Source
- Terpenes, aromatic compounds found in many plants, including marijuana, may have therapeutic benefits for RA. Some terpenes have anti-inflammatory and analgesic properties. A study published in the journal Natural Product Research found that a specific terpene called beta-caryophyllene can reduce inflammation in a model of RA in rats. Source
- A review published in the journal Molecules found that terpenes may have therapeutic potential for the treatment of RA, but more research is needed to explore their potential benefits in humans. Source
Overall, research suggests that the active compounds in marijuana, particularly cannabinoids, and terpenes, may be effective treatments for rheumatoid arthritis. However, more research is needed to understand their therapeutic effects.